Influences of Immunosuppressive Agents,FK506 and Cyclosporin on Systemic Candida albicans Infection in Mice |
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| Authors: | Ito Emiko Tanaka Yasushi |
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| Institution: | (1) Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, 1-8-1, Inohana, Chuoku Chiba 260, Japan |
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| Abstract: | The effects of the immunosuppressive agents FK506 (tacrolimus) and cyclosporin (CyA) on Candida albicans infection in mice
were compared with those of cyclophosphamide. FK506 and CyA did not exacerbate C. albicans infection in mice when the effects
were determined on the basis of survival ratio and colony forming units (CFU) in the kidney, although cyclophosphamide (CY)
impaired the host defence mechanisms of mice against C. albicans infection. The effects of FK506 and CyA on the body weight
of mice, histopathological changes of lymphoid tissues and formation of granulomas in kidney were also studied in comparison
with those of CY.
This revised version was published online in June 2006 with corrections to the Cover Date. |
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| Keywords: | Candida albicans cyclosporin cyclophosphamide FK506 (tacrolimus) immunosuppressive agents infection pathology |
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