Identification of prostaglandin D2 as a major prostaglandin in homogenates of rat brain |
| |
Authors: | M.Saeed Abdel-Halim, Mats Hamberg, Birgitta Sj quist,Erik ng rd |
| |
Affiliation: | Departments of Pharmacology and Chemistry, Karolinska Institute, 104 01 Stockholm, Sweden |
| |
Abstract: | Prostaglandin (PG) E2, D2, F2α and thromboxane B2 (TxB2) were determined in homogenates of rat brain by gas-chromatography - mass spectrometry. The level of PGD2 was 735 ± 19 ng/g, of PGF2α 150 ± 13 ng/g, of TxB2 112 ng/g and of PGE2 86 ± 8 ng/g. The same relative proportions of cyclo-oxygenase products were found in incubates of unstimulated sliced rat brain. 14C-PGH2 was converted in high yield into PGD2 by enzyme(s)_present in the soluble fraction of the homogenate. These results indicate that PGD2 is the major cyclooxygenase product in the central nervous system of the rat. |
| |
Keywords: | correspondence |
本文献已被 ScienceDirect 等数据库收录! |
|