The impact of the bystander effect on the low-dose hypersensitivity phenomenon |
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Authors: | Otilia Nuta Firouz Darroudi |
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Institution: | (1) Department of Toxicogenetics, Leiden University Medical Center, Einthovenweg 20, PO Box 9600, 2300 RC Leiden, The Netherlands;(2) Radiation and Environmental Science Centre, Focas Institute, Dublin Institute of Technology, Kevin Street, Dublin 8, Republic of Ireland |
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Abstract: | The aim of this study was to investigate the possible relationship between the bystander effect and the low-dose hypersensitivity/increased
radio-resistance phenomenon in BJ fibroblast cells taking as response criteria different end points of radiation damage such
as cell survival, chromosomal damage (as detected by using micronucleus assay) and double strand breaks (DSBs) of the DNA.
Although γ-H2AX foci were observed in confluent bystander BJ cells, our data suggest that X-irradiation does not lead to a
significant rate of DSBs in bystander cells. Thus, neither bystander effect induced unstable chromosomal aberrations nor bystander
effect induced DSBs are sufficiently pronounced to explain the apparent relationship between bystander effect and low-dose
hypersensitivity. The experiments described here suggest that the hyper-radiosensitivity phenomenon might be related to bystander
factor induced cell inactivation in the low-dose region (lower than 1 Gy). |
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