Identification of a truncated form of methionine sulfoxide reductase a expressed in mouse embryonic stem cells |
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| Authors: | Pingping Jia Chi Zhang Yuanyuan Jia Keith A Webster Xupei Huang Andrei A Kochegarov Sharon L Lemanski Larry F Lemanski |
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| Institution: | (1) Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL 33136, USA;(2) Department of Molecular and Cellular Pharmacology, University of Miami, Miller School of Medicine, Miami, FL 33431, USA;(3) Department of Biomedical Science, Florida Atlantic University, Boca Raton, FL 33101, USA;(4) Department of Anatomy and Cell Biology and The Cardiovascular Research Center, School of Medicine, Temple University, Philadelphia, Pennsylvania 19140, USA;(5) Department of Biological and Environmental Sciences, Texas A&M University-Commerce, Commerce, TX 75429-3011, USA |
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| Abstract: | Background Methionine Sulfoxide Reductase A (MsrA), an enzyme in the Msr gene family, is important in the cellular anti-oxidative stress
defense mechanism. It acts by reducing the oxidized methionine sulfoxide in proteins back to sulfide and by reducing the cellular
level of reactive oxygen species. MsrA, the only enzyme in the Msr gene family that can reduce the S-form epimers of methionine
sulfoxide, has been located in different cellular compartments including mitochondria, cytosol and nuclei of various cell
lines. |
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