The extract from hop cones in plasma protects against changes following exposure to peroxynitrite |
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Authors: | Beata Olas Joanna Ko?odziejczyk-Czepas Barbara Wachowicz Dariusz J?drejek Anna Stochmal Wies?aw Oleszek |
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Institution: | 1.Department of General Biochemistry,University of Lodz,Lodz,Poland;2.Department of Biochemistry, Institute of Soil Science and Plant Cultivation,State Research Institute,Pulawy,Poland |
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Abstract: | Humulus lupulus (Cannabaceae) is well known throughout the world as a raw material in the brewing industry. The antioxidative action of hop cones is poorly
understood, therefore the aim of our present study was to investigate in vitro changes in human plasma induced by peroxynitrite in the presence of the highly purified extract from hop cones (Humulus lupulus). The aim of our study was also to explain the effect of the extract from hop cones on coagulation activity of human plasma
treated with peroxynitrite. The action of the extract from hop cones was compared with the properties of a well-characterized
commercial monomeric polyphenol — resveratrol (3,4′,5-trihydroxystilbene). The tested plant extract, like resveratrol, significantly
inhibited protein carbonylation and nitration in plasma treated with ONOO−(0.1 mM). The extract from hop cones, like resveratrol, also caused a distinct reduction of plasma lipid peroxidation induced
by ONOO−. Moreover, the tested extract modulated the coagulation properties of plasma treated with peroxynitrite. It seems that antioxidative
activities of the highly purified extract from hop cones may be responsible for its medicinal properties. |
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