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Mechanism of acetate oxidation to CO2 with elemental sulfur in Desulfuromonas acetoxidans |
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| Authors: | Norbert A Gebhardt Rudolf K Thauer Dietmar Linder Paul-M Kaulfers Norbert Pfennig |
| Institution: | (1) Fachbereich Biologie, Mikrobiologie, Philipps-Universität Marburg, D-3550 Marburg, Federal Republic of Germany;(2) Fakultät für Biologie, Universität Konstanz, D-7750 Konstanz, Federal Republic of Germany;(3) Fachbereich Humammedizin, Biochemisches Institut, Justus-Liebig-Universität, D-6300 Gießen, Federal Republic of Germany;(4) Institut für Med. Mikrobiologie und Immunologie, Universität Hamburg, Krankenhaus Eppendorf, D-2000 Hamburg 20, Federal Republic of Germany |
| Abstract: | The strict anaerobe Desulfuromonas acetoxidans can oxidize acetate to CO2 with elemental sulfur as electron acceptor. 14C-labelling experiments and enzyme studies are described revealing that acetate oxidation proceeds via the citric acid cycle with the synthesis of oxaloacetate from acetate and 2 CO2 via pyruvate as anaplerotic reaction. An oxidation of acetate via one carbon unit intermediates as proposed for anaerobic bacteria fermenting acetate to 2 CO2 and 4 H2 was excluded.Dedicated to Professor Dr. Gerhart Drews on the occasion of his 60th birthday |
| Keywords: | Desulfuromonas acetoxidans Acetate oxidation Sulfur reduction Acetate activation Citric acid cycle Anaplerotic reaction Citrate (si)-synthase Succinate dehydrogenase Succinyl-CoA: acetate CoA transferase 2-Oxoglutarate: ferredoxin oxidoreductase |
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