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Molecular chaperones: Clasping the prize
Authors:Mary-Jane Gething
Affiliation:1Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Victoria 3052, Australia
Abstract:The three-dimensional structure of the substrate-binding domain of DnaK, a bacterial Hsp70, shows how such molecular chaperones can be so promiscuous in recognizing different proteins, yet so accurate in discriminating between unfolded and folded forms of their polypeptide substrates.
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