IMMUNOCHEMICAL IDENTIFICATION OF THE 1,25-DIHYDROXYVITAMIN D3RECEPTOR PROTEIN IN HUMAN HEART |
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| Authors: | TIMOTHY D O'CONNELL ROBERT U SIMPSON |
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| Institution: | 1. Student Research Committee, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran;2. PhD of physiology, Faculty of Nursing and Midwifery, Qom University of Medical Sciences, Qom, Iran;3. PhD of physiology, Department of Physiology, Molecular and Cell Biology Research Center and Immunogenetics Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran;2. University of Toronto, Toronto, ON, Canada;3. Terrence Donnelly Centre for Cellular and Biomolecular Research, Toronto, ON, Canada |
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| Abstract: | A number of recent clinical observations suggest that vitamin D3plays an important role in maintaining normal cardiovascular function, either directly through its receptor in cardiac muscle, or indirectly through its infuence on circulating levels of calcium or on other regulatory factors. By using an antibody directed against the recombinant vitamin D3receptor, we have identified the receptor protein for 1,25(OH)2D3in tissue from two human hearts. The identification of the 1,25(OH)2D3receptor in human heart lends credence to the hypothesis that 1,25(OH)2D3directly effects the human heart and may be involved in several clinically relevant pathological conditions involving the vitamin D3endocrine system. |
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| Keywords: | vitamin D receptor human heart |
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