CONNEXIN EXPRESSION AND GAP JUNCTIONS IN THE MAMMARY GLAND |
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| Authors: | PAUL MONAGHAN DAVID MOSS |
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| Institution: | 1. Cancer and Vascular Biology Research Center, Bruce Rappaport Faculty of Medicine, Technion, Haifa 31096, Israel;2. Department of Pathology, Ramabm Health Care Campus, Haifa, Israel;1. Henan Engineering Laboratory for Big Data Statistical Analysis and Optimal Control, College of Mathematics and Information Science, Henan Normal University, Xinxiang 453007, China;2. College of Information Science and Technology and the College of Cyber Security, Jinan University, Guangzhou 510632, China |
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| Abstract: | Gap junctional communication plays a vital role in embryogenesis, cell differentiation and the co-ordination of tissue responses. Gap junctions are formed by a family of closely-related proteins called connexins which show tissue-specific patterns of expression. The role of gap junctions in the mammary gland remains unclear. The lumena of mammary gland ducts are lined by luminal cells with an outer layer of basal cells. In rodents, the luminal cells express connexin26 only during pregnancy and lactation and the basal cells, in some reports, express connexin43. In the normal human breast the basal cells express connexin43, although human mammary epithelial cellsin vitrohave been reported to express both connexin26 and connexin43. Analysis of connexin expression at the molecular level is now bringing new insights into the structure and function of gap junctions in a range of normal and pathological cell systems. |
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| Keywords: | gap junctions connexins mammary gland lactation |
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