| 微管解聚型驱动蛋白的结构与功能 |
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| 引用本文： | 蒋蕾蕾,吴作基,王春光.微管解聚型驱动蛋白的结构与功能[J].细胞生物学杂志,2008,30(2):137-141. |
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| 作者姓名： | 蒋蕾蕾 吴作基 王春光 |
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| 作者单位： | 同济大学生命科学与技术学院蛋白质研究所,上海200092 |
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| 基金项目： | 国家自然科学基金
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上海市科技攻关项目 |
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| 摘 要： | Kin-I 驱动蛋白(Kin-I kinesins)是一类重要的微管调节蛋白,具有依赖ATP的微管解聚活性.这类驱动蛋白在神经元的发育、纺锤体的组装和染色体的分离过程中起着重要的作用.自被发现以来的十几年里,人们对Kin-I驱动蛋白做了大量的研究工作.现对Kin-I驱动蛋白的结构、微管解聚活性及生理功能等方面进行简要综述.
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| 关 键 词： | Kin-I驱动蛋白 微管 ATPase 解聚 Kin-I kinesins microtubule ATPase depolymerization SUMO 翻译 蛋白质 修饰 系统 in Vivo biological significance protein strategy developing therapeutic reagents human diseases cancer neurodegenerative disorder genome organization repair |
| 修稿时间： | 2007年9月10日 |
Structure and Function of Microtubule-depolymerizing Kin-I Kinesins |
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| Lei-Lei Jiang,Zuo-Ji Wu,Chun-Guang Wang.Structure and Function of Microtubule-depolymerizing Kin-I Kinesins[J].Chinese Journal of Cell Biology,2008,30(2):137-141. |
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| Authors: | Lei-Lei Jiang Zuo-Ji Wu Chun-Guang Wang |
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| Abstract: | Kin-I kinesins are one important class of microtubule regulatory proteins which can depolymerize microtubules in an ATP-dependent manner. They have critical functions in neuronal development, spindle assembly and chromosome segregation. Over the past ten years, a big amount of studies have been done to understand Kin-I kinesins. Here, several aspects of Kin-I kinesins are reviewed briefly, including the structure, mechanism of microtubule depolymerization and their physiological functions. |
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| Keywords: | Kin-I kinesins microtubule ATPase depolymerization |
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