Myocardial tissue engineering: toward a bioartificial pump |
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Authors: | Sekine Hidekazu Shimizu Tatsuya Okano Teruo |
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Institution: | (1) Institute of Advanced Biomedical Engineering and Science, Tokyo Women’s Medical University, TWIns, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan; |
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Abstract: | Regenerative therapies, including cell injection and bioengineered tissue transplantation, have the potential to treat severe
heart failure. Direct implantation of isolated skeletal myoblasts and bone-marrow-derived cells has already been clinically
performed and research on fabricating three-dimensional (3-D) cardiac grafts using tissue engineering technologies has also
now been initiated. In contrast to conventional scaffold-based methods, we have proposed cell sheet-based tissue engineering,
which involves stacking confluently cultured cell sheets to construct 3-D cell-dense tissues. Upon layering, individual cardiac
cell sheets integrate to form a single, continuous, cell-dense tissue that resembles native cardiac tissue. The transplantation
of layered cardiac cell sheets is able to repair damaged hearts. As the next step, we have attempted to promote neovascularization
within bioengineered myocardial tissues to overcome the longstanding limitations of engineered tissue thickness. Finally,
as a possible advanced therapy, we are now trying to fabricate functional myocardial tubes that may have a potential for circulatory
support. Cell sheet-based tissue engineering technologies therefore show an enormous promise as a novel approach in the field
of myocardial tissue engineering. |
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Keywords: | |
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