Cell cycle and cell-fate determination in Drosophila neural cell lineages |
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Authors: | Fichelson Pierre Audibert Agnès Simon Françoise Gho Michel |
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Institution: | Institut Jacques Monod, CNRS, University Paris 6 and 7, 2 Place Jussieu, 75005 Paris, France. |
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Abstract: | "Normal" development requires a finely tuned equilibrium between cell differentiation and cell proliferation. Important issues in development include whether the cell cycle controls the cell-fate determination and whether cell identity in turn regulates cell-cycle progression. Although, these issues are of general biological relevance, stereotyped Drosophila neural lineages are particularly suited to address these questions and have provided insights into the links between cell-cycle progression and cell-fate specification. |
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