Synthesis and the structure of mixed carboxylatoplatinum(IV) complexes involving one trifluoroacetate ligand |
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Authors: | Hae Jin Kim Youn Soo Sohn |
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Affiliation: | Department of Chemistry, Division of Nano Science, Ewha Womans University, Seoul 120-750, South Korea |
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Abstract: | Mono(trifluoroacetato)platinum(IV) complexes of the formula [PtIV(dach)L3(TFAc)] (dach = trans-(±)-1,2-diaminocyclohexane, TFAc = trifluoroacetate, L = acetate or propionate) could be prepared from the reaction of [PtIV(dach)L3(OH)] with trifluoroacetic anhydride in the presence of a base and the crystal structure of compound 4 was determined by X-ray crystallography. In vitro antitumor activity of complex 4 (ED50 = 3.1 μM) was found to be much higher than carboplatin (ED50 = 10.2 μM). |
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Keywords: | Platinum(IV) Antitumor drug Electrophilic substitution |
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