Heat-killed Salmonella typhi induces the release of prostaglandins and leukotrienes from mouse macrophages |
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Authors: | T Pang S Devi S Puthucheary N Pawlowski |
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Institution: | Institute for Advanced Studies, University of Malaya, Kuala Lumpur. |
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Abstract: | Mouse macrophages pre-labeled with 3H]arachidonic acid (20:4) were shown to release metabolites generated by the lipoxygenase and cyclo-oxygenase pathways following in vitro addition of heat-killed Salmonella typhi. These metabolites were maximally released after 60-90 min of incubation and consisted of prostaglandins (85%), leukotriene C (6%), di-HETEs, leukotrienes D and E (4%), mono-HETEs (2%) and other metabolites (3%). Of the metabolites generated by the cyclo-oxygenase pathway (prostaglandins), 6-keto PGF1 alpha and PGE2 were generated at a ratio of 1.2 to 1. The significance and importance of these results are discussed. |
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