Neurotrophic peptide aldehydes: solid phase synthesis of fellutamide B and a simplified analog |
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Authors: | Schneekloth John S Sanders John L Hines John Crews Craig M |
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Affiliation: | Department of Molecular, Cellular, and Developmental Biology, Yale University, PO Box 208103, New Haven, CT 06520-8103, USA. |
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Abstract: | A combination of solid phase and solution phase synthetic methods have been used to complete the total synthesis of the neurotrophic lipopeptide aldehyde fellutamide B (2). The beta-hydroxy aliphatic tail was prepared by regioselective reductive opening of a cyclic sulfate, and later coupled to a solid phase resin. The synthetic compound was then examined in cytotoxicity and nerve growth factor (NGF) induction assays. A simplified analog of fellutamide B also showed activity. |
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