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SOX17 integrates HOXA and arterial programs in hemogenic endothelium to drive definitive lympho-myeloid hematopoiesis
Authors:Ho Sun Jung  Gene Uenishi  Mi Ae Park  Peng Liu  Kran Suknuntha  Matthew Raymond  Yoon Jung Choi  James A. Thomson  Irene M. Ong  Igor I. Slukvin
Affiliation:1. Wisconsin National Primate Research Center, University of Wisconsin Graduate School, 1220 Capitol Court, Madison, WI 53715, USA;2. Departments of Statistics and of Biostatistics and Medical Informatics, Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI, USA;3. Chakri Naruebodindra Medical Institute, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Samut Prakan 10540, Thailand;4. Department of Pathology and Laboratory Medicine, University of Wisconsin Medical School, 600 Highland Avenue, Madison, WI 53792, USA;5. Morgridge Institute for Research, 330 N. Orchard Street, Madison, WI 53715, USA;6. Department of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53707-7365, USA;7. Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA 93106, USA
Abstract:
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  • Keywords:SOX17  hematopietic development  hemogenic endothleium specification  arterial hemogenic endothelium  HOXA  NOTCH signaling  human pluripotent stem cells  CDX2
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