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Tunable,division-independent control of gene activation timing by a polycomb switch
Authors:Nicholas A Pease  Phuc HB Nguyen  Marcus A Woodworth  Kenneth KH Ng  Blythe Irwin  Joshua C Vaughan  Hao Yuan Kueh
Institution:1. Department of Bioengineering, University of Washington, Seattle, WA 98195, USA;2. Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA;3. Molecular Engineering and Sciences Institute, University of Washington, Seattle, WA 98195, USA;4. Biological Physics, Structure and Design Program, University of Washington, Seattle, WA 98195, USA;5. Department of Chemistry, University of Washington, Seattle, WA 98195, USA;6. Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195, USA;7. Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98195, USA
Abstract:
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  • Keywords:T cell development  gene regulation  epigenetic switch  timing control  stochasticity  tunability  post-translational histone modifications  chromatin compaction
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