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Kmt2c mutations enhance HSC self-renewal capacity and convey a selective advantage after chemotherapy
Authors:Ran Chen  Theresa Okeyo-Owuor  Riddhi M Patel  Emily B Casey  Andrew S Cluster  Wei Yang  Jeffrey A Magee
Institution:1. Department of Pediatrics, Division of Hematology and Oncology, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, MO 63110, USA;2. Department of Genetics, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, MO 63110, USA
Abstract:
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  • Keywords:Kmt2c  MLL3  hematopoietic stem cell  therapy-related leukemia  interleukin-1  self-renewal  HSC exhaustion
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