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Prolonged mitosis causes separase deregulation and chromosome nondisjunction
Authors:Norihisa Shindo  Makoto Otsuki  Kazuhiko SK Uchida  Toru Hirota
Institution:1. Division of Experimental Pathology, Cancer Institute of the Japanese Foundation for Cancer Research (JFCR), Ariake 3-8-31 Koto-ku, 135-8550 Tokyo, Japan
Abstract:
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  • Keywords:cancer cells  chromosomal instability  chromosome segregation  metaphase-to-anaphase transition  mitosis  separase sensor
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