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Blockade of 6-phosphogluconate dehydrogenase generates CD8+ effector T cells with enhanced anti-tumor function
Authors:Saeed Daneshmandi  Teresa Cassel  Penghui Lin  Richard M. Higashi  Gerburg M. Wulf  Vassiliki A. Boussiotis  Teresa W.-M. Fan  Pankaj Seth
Affiliation:1. Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA;2. Division of Interdisciplinary Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA;3. Center for Environmental and Systems Biochemistry, University of Kentucky, Lexington, KY 40536, USA;4. Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY 40536, USA;5. Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Abstract:
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  • Keywords:6PGD  pentose phosphate pathway  effector T cells  metabolism  reactive oxygen species  tumor immunotherapy
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