首页 | 本学科首页   官方微博 | 高级检索  
     


Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins
Authors:Ryosuke Shirasaki  Geoffrey M. Matthews  Sara Gandolfi  Ricardo de Matos Simoes  Dennis L. Buckley  Joseline Raja Vora  Quinlan L. Sievers  Johanna B. Brüggenthies  Olga Dashevsky  Haley Poarch  Huihui Tang  Megan A. Bariteau  Michal Sheffer  Yiguo Hu  Sondra L. Downey-Kopyscinski  Paul J. Hengeveld  Brian J. Glassner  Eugen Dhimolea  Constantine S. Mitsiades
Affiliation:1. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA;2. Harvard Medical School, Boston, MA, USA;3. Broad Institute of MIT and Harvard, Cambridge, MA, USA;4. Ludwig Center at Harvard, Boston, MA, USA;5. Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA;6. Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA;7. Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute and Harvard T.H. Chan School of Public Health, Boston, MA, USA;8. Department of Hematology, Amsterdam UMC, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, the Netherlands;9. Multiple Myeloma Research Foundation, Norwalk, CT, USA;10. University of Florida Health Cancer Center, Gainesville, FL, USA;11. Translational Genomics Research Institute, Phoenix, AZ, USA;12. Department of Hematology and Medical Oncology and the Winship Cancer Institute, Emory University, Atlanta, GA, USA
Abstract:
><ol class=
  • Download : Download high-res image (204KB)
  • Download : Download full-size image
  • Keywords:heterobifunctional proteolysis-targeting chimeric compounds  pharmacological degraders  resistance  CRISPR  CRBN  VHL  myeloma  PROTAC  E3 ligase  CRISPR activation
    本文献已被 ScienceDirect 等数据库收录!
    设为首页 | 免责声明 | 关于勤云 | 加入收藏

    Copyright©北京勤云科技发展有限公司  京ICP备09084417号