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Itaconate confers tolerance to late NLRP3 inflammasome activation
Authors:Monika Bambouskova  Lucie Potuckova  Tomas Paulenda  Martina Kerndl  Denis A. Mogilenko  Kate Lizotte  Amanda Swain  Sebastian Hayes  Ryan D. Sheldon  Hyeryun Kim  Unnati Kapadnis  Abigail E. Ellis  Christine Isaguirre  Samantha Burdess  Anwesha Laha  Gaya K. Amarasinghe  Victor Chubukov  Thomas P. Roddy  Maxim N. Artyomov
Affiliation:1. Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA;2. Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA;3. Institute for Vascular Biology, Centre for Physiology and Pharmacology, Medical University Vienna, 1090 Vienna, Austria;4. Christian Doppler Laboratory for Arginine Metabolism in Rheumatoid Arthritis and Multiple Sclerosis, 1090 Vienna, Austria;5. Agios Pharmaceuticals, 88 Sidney Street, Cambridge, MA 02139, USA;6. Van Andel Research Institute, Metabolic and Nutritional Programming, Center for Cancer and Cell Biology, Grand Rapids, MI 49503, USA;7. Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA;8. The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO 63110, USA
Abstract:
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  • Keywords:immunometabolism  macrophages  itaconate  inflammasome  innate immunity
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