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Tim4 recognizes carbon nanotubes and mediates phagocytosis leading to granuloma formation
Authors:Satoshi Omori  Misato Tsugita  Yasuto Hoshikawa  Masanobu Morita  Fumiya Ito  Shin-Ichiro Yamaguchi  Qilin Xie  Osamu Noyori  Tomoya Yamaguchi  Ayato Takada  Tatsuya Saitoh  Shinya Toyokuni  Hisaya Akiba  Shigekazu Nagata  Kengo Kinoshita  Masafumi Nakayama
Institution:1. Graduate School of Information Sciences, Tohoku University, Sendai, Japan;2. Frontier Research Institute for Interdisciplinary Sciences, Tohoku University, Sendai, Japan;3. Institute of Multidisciplinary Research for Advanced Materials (IMRAM), Tohoku University, Sendai, Japan;4. Department of Environmental Medicine and Molecular Toxicology, Tohoku University Graduate School of Medicine, Sendai, Japan;5. Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, Nagoya, Japan;6. CREST, Japan Science and Technology Agency (JST), Kawaguchi, Japan;7. Laboratory of Immunology and Microbiology, College of Pharmaceutical Sciences, Ritsumeikan University, Kusatsu, Japan;8. Department of Cancer Biology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan;9. PRESTO, JST, Kawaguchi, Japan;10. Division of Global Epidemiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan;11. Laboratory of Bioresponse Regulation, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Japan;12. Center for Low-temperature Plasma Sciences, Nagoya University, Nagoya, Japan;13. Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan;14. Laboratory of Biochemistry and Immunology, Immunology Frontier Research Center, Osaka University, Suita, Japan;15. Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan
Abstract:
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  • Keywords:Tim-4  Tim-1  Caspase-1  IL-1β  nanomaterials  molecular dynamics simulation
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