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Excision of mutagenic replication-blocking lesions suppresses cancer but promotes cytotoxicity and lethality in nitrosamine-exposed mice
Authors:Jennifer E. Kay  Joshua J. Corrigan  Amanda L. Armijo  Ilana S. Nazari  Ishwar N. Kohale  Dorothea K. Torous  Svetlana L. Avlasevich  Robert G. Croy  Dushan N. Wadduwage  Sebastian E. Carrasco  Stephen D. Dertinger  Forest M. White  John M. Essigmann  Leona D. Samson  Bevin P. Engelward
Affiliation:1. Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 01239, USA;2. Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA 01239, USA;3. Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 01239, USA;4. David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 01239, USA;5. Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, MA 01239, USA;6. Litron Laboratories, Rochester, NY 14623, USA;7. The John Harvard Distinguished Science Fellows Program, Harvard University, Cambridge, MA 02138, USA;8. Center for Advanced Imaging, Harvard University, Cambridge, MA 02138, USA;9. Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 01239, USA;10. Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 01239, USA
Abstract:
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  • Keywords:alkyladenine DNA glycosylase  DNA damage  replication-blocking lesion  DNA strand break  nitrosamine  cancer  mutation  liver
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