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Excision of mutagenic replication-blocking lesions suppresses cancer but promotes cytotoxicity and lethality in nitrosamine-exposed mice
Authors:Jennifer E Kay  Joshua J Corrigan  Amanda L Armijo  Ilana S Nazari  Ishwar N Kohale  Dorothea K Torous  Svetlana L Avlasevich  Robert G Croy  Dushan N Wadduwage  Sebastian E Carrasco  Stephen D Dertinger  Forest M White  John M Essigmann  Leona D Samson  Bevin P Engelward
Institution:1. Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 01239, USA;2. Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA 01239, USA;3. Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 01239, USA;4. David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 01239, USA;5. Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, MA 01239, USA;6. Litron Laboratories, Rochester, NY 14623, USA;7. The John Harvard Distinguished Science Fellows Program, Harvard University, Cambridge, MA 02138, USA;8. Center for Advanced Imaging, Harvard University, Cambridge, MA 02138, USA;9. Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 01239, USA;10. Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 01239, USA
Abstract:
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  • Keywords:alkyladenine DNA glycosylase  DNA damage  replication-blocking lesion  DNA strand break  nitrosamine  cancer  mutation  liver
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