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Presynaptic activity and protein turnover are correlated at the single-synapse level
Authors:Sebastian Jähne  Fabian Mikulasch  Helge G.H. Heuer  Sven Truckenbrodt  Paola Agüi-Gonzalez  Katharina Grewe  Angela Vogts  Silvio O. Rizzoli  Viola Priesemann
Affiliation:1. Department of Neuro- and Sensory Physiology, University Medical Center Göttingen, Humboldtallee 23, 37073 Göttingen, Germany;2. Max-Planck-Institute for Dynamics and Self-Organization, Am Faßberg 17, 37077 Göttingen, Germany;3. Faculty of Physics, Georg-August-University of Göttingen, Friedrich-Hund-Platz 1, 37077 Göttingen, Germany;4. NanoSIMS lab, Leibniz Institute for Baltic Sea Research Warnemünde (IOW), Seestraße 15, 18119 Rostock, Germany;5. Center for Biostructural Imaging of Neurodegeneration (BIN), von Siebold Str. 3a, 37075 Göttingen, Germany;6. Cluster of Excellence “Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells” (MBExC), University of Göttingen, 37073 Göttingen, Germany;7. Bernstein-Center for Computational Neuroscience, Heinrich-Düker-Weg 12, 37073 Göttingen, Germany
Abstract:
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  • Keywords:synapse  synaptic vesicle  turnover  aging  microscopy  imaging mass spectrometry  mathematical modeling
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