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Functional cooperation between co-amplified genes promotes aggressive phenotypes of HER2-positive breast cancer
Authors:Yongguang Yang  Marissa Leonard  Zhenhua Luo  Syn Yeo  Gregory Bick  Mingang Hao  Chunmiao Cai  Mahmoud Charif  Jiang Wang  Jun-Lin Guan  Elyse E Lower  Xiaoting Zhang
Institution:1. Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA;2. Graduate Program in Cancer and Cell Biology, Vontz Center for Molecular Studies, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA;3. The Liver Care Center and Divisions of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA;4. Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA;5. Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA;6. University of Cincinnati Cancer Center, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
Abstract:
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  • Keywords:HER2  MED1  Jab1  cancer stem cell  tumor metastasis  therapeutic resistance
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