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Nod1 promotes colorectal carcinogenesis by regulating the immunosuppressive functions of tumor-infiltrating myeloid cells
Authors:Charles Maisonneuve  Derek K.L. Tsang  Elisabeth G. Foerster  Lukian Maxence Robert  Tapas Mukherjee  Dave Prescott  Ivan Tattoli  Paul Lemire  Daniel A. Winer  Shawn Winer  Catherine J. Streutker  Kaoru Geddes  Ken Cadwell  Richard L. Ferrero  Alberto Martin  Stephen E. Girardin  Dana J. Philpott
Affiliation:1. Department of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada;2. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada;3. Department of Pathology, Toronto General Hospital, University of Toronto, Toronto, ON M5S 1A8, Canada;4. Saint Michael’s Hospital, Toronto, ON M5B 1W8, Canada;5. Kimmel Center for Biology and Medicine at the Skirball Institute, New York Grossman University Grossman School of Medicine, New York, NY 10016, USA;6. Department of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA;7. Division of Gastroenterology and Hepatology, Department of Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA;8. Buck Institute for Research on Aging, Novato, CA 94945, USA;9. Department of Molecular and Translational Sciences, Monash University, Clayton, 3800 VIC, Australia;10. Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, 3168 VIC, Australia;11. Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, 3800 VIC, Australia
Abstract:
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  • Keywords:Nod1 receptor  microbiota  colon cancer  MDSC  TAM  arginase-1  TME  autophagy  Atg16L1  immunosuppression
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