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FOXO1 constrains activation and regulates senescence in CD8 T cells
Authors:Arnaud Delpoux  Nimi Marcel  Rodrigo Hess Michelini  Carol D. Katayama  Karmel A. Allison  Christopher K. Glass  Sergio M. Quiñones-Parra  Cornelis Murre  Liyen Loh  Katherine Kedzierska  Martha Lappas  Stephen M. Hedrick  Andrew L. Doedens
Affiliation:1. Division of Biological Sciences, Molecular Biology Section, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0377, USA;2. Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0377, USA;3. Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Parkville, VIC, Australia;4. Obstetrics, Nutrition, and Endocrinology Group, Department of Obstetrics & Gynaecology, University of Melbourne, Mercy Hospital for Women, Heidelberg, VIC, Australia
Abstract:
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  • Keywords:T cells  CD8  quiescence  multipotency  FOXO1  AP-1  aging  immune senescence  effector  memory
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