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Whole-genome characterization of lung adenocarcinomas lacking alterations in the RTK/RAS/RAF pathway
Authors:Jian Carrot-Zhang  Xiaotong Yao  Siddhartha Devarakonda  Aditya Deshpande  Jeffrey S. Damrauer  Tiago Chedraoui Silva  Christopher K. Wong  Hyo Young Choi  Ina Felau  A. Gordon Robertson  Mauro A.A. Castro  Lisui Bao  Esther Rheinbay  Eric Minwei Liu  Tuan Trieu  David Haan  Christina Yau  Toshinori Hinoue  Marcin Imielinski
Affiliation:1. Dana-Farber Cancer Institute, Boston, MA, USA;2. Broad Institute of MIT and Harvard, Cambridge, MA, USA;3. Harvard Medical School, Boston, MA, USA;4. Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA;5. New York Genome Center, New York, NY, USA;6. Tri-institutional Ph.D. Program in Computational Biology and Medicine, New York, NY, USA;7. Section of Medical Oncology, Division of Oncology, Washington University School of Medicine, St. Louis, MO, USA;8. Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA;9. Department of Genetics, Computational Medicine Program, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA;10. Center for Bioinformatics and Functional Genomics, Cedars-Sinai Medical Center, Los Angeles, CA, USA;11. Department of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, CA, USA;12. University of Tennessee Health Science Center, UTHSC Center for Cancer Research, TN, USA;13. National Cancer Institute, Bethesda, MD, USA;14. Canada’s Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, BC, Canada;15. Bioinformatics and Systems Biology Laboratory, Federal University of Paraná, Curitiba, PR, Brazil;16. Ben May Department for Cancer Research, University of Chicago, Chicago, IL, USA;17. Massachusetts General Hospital Cancer Center, Boston, MA, USA;18. University of California, San Francisco, San Francisco, CA, USA;19. Buck Institute for Research on Aging, Novato, CA, USA;20. Van Andel Institute, Grand Rapids, MI, USA;21. Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA;22. McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO, USA;23. Fred Hutchinson Cancer Research Center, Seattle, WA, USA;24. Department of Medicine, Brigham and Women’s Hospital, Boston, MA, USA;25. Thoracic Pathology, Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA;26. Division of Computational Biomedicine, Boston University School of Medicine, Boston, MA, USA;27. Department of Pathology, University Health Network, Princess Margaret Cancer Centre, Toronto, ON, Canada;28. Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, Hebrew University, Jerusalem, Israel;29. Caryl and Israel Englander Institute for Precision Medicine and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA
Abstract:
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  • Keywords:lung adenocarcinoma  whole genome sequencing  structural variation  precision oncology  oncogene  driver  TCGA  noncoding  genome analysis  tumor suppressor
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