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A FOXO-dependent replication checkpoint restricts proliferation of damaged cells
Authors:Marten Hornsveld  Femke M Feringa  Lenno Krenning  Jeroen van den Berg  Lydia MM Smits  Nguyen BT Nguyen  Maria J Rodríguez-Colman  Tobias B Dansen  René H Medema  Boudewijn MT Burgering
Institution:1. Oncode Institute, Department of Cell and Chemical Biology, Leiden University Medical Center, 2333 Leiden, the Netherlands;2. Oncode Institute, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, 3584 Utrecht, the Netherlands;3. Oncode Institute, Division of Cell Biology, Netherlands Cancer Institute, 1066 Amsterdam, the Netherlands;4. Department of Molecular and Cellular Neurobiology, Faculty of Science, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, 1081 Amsterdam, the Netherlands;5. Oncode Institute, Hubrecht Institute–KNAW (Royal Netherlands Academy of Arts and Sciences), 3584 Utrecht, the Netherlands
Abstract:
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  • Keywords:DNA replication stress  DNA damage checkpoint  checkpoint recovery  cell cycle exit  genomic instability  FOXO  EMI1  senescence
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