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Methylglyoxal-induced mutation to 6-thioguanine resistance in V79 cells |
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| Authors: | E Cajelli R Canonero A Martelli G Brambilla |
| Abstract: | Methylglyoxal, at concentrations ranging from 0.16 to 1.5 mM, caused a dose-dependent increase in the frequency of HGPRT-deficient mutants in V79 cells. Its mutagenic activity was reduced when V79 cells were co-cultured with freshly isolated rat hepatocytes. |
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