How signaling proteins integrate multiple inputs: a comparison of N-WASP and Cdk2 |
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Authors: | Prehoda Kenneth E Lim Wendell A |
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Institution: | Institute of Molecular Biology, Department of Chemistry, 1229 University of Oregon, Eugene, OR 97403-1229, USA. |
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Abstract: | Signal transduction proteins that can integrate multiple upstream signals play a critical role in the complex regulatory circuits that control cellular behavior. The two signaling node proteins cyclin-dependent kinase 2 and the actin regulator neuronal Wiskott-Aldrich syndrome protein have qualitatively similar signaling properties. Recent studies, however, reveal that these proteins utilize distinct mechanisms of signal integration, leading to subtle but important quantitative differences in behavior. |
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