The formation of lipid-bound carnitine derivatives in the fat body of Phormia regina |
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| Authors: | C Mezei R W Newburgh |
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| Affiliation: | 1. Institute of Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Freiburg, Freiburg, Germany;2. Faculty of Biology, University of Freiburg, Freiburg, Germany;3. Heart Center, Department of Congenital Heart Defects and Pediatric Cardiology, University of Freiburg, Freiburg, Germany;4. Heart Center, Department of Cardiology and Angiology I, Faculty of Medicine, University of Freiburg, Freiburg, Germany;5. Institute for Pharmacology and Clinical Pharmacology, University of Düsseldorf, Düsseldorf, Germany;6. Heart Center, Department of Cardiovascular Surgery, University of Freiburg, Freiburg, Germany;7. Institute of Human Genetics, Genetic Epidemiology, University of Münster, Münster, Germany;8. Pharmazentrum, Allgemeine Pharmakologie und Toxikologie, Goethe Universität, Frankfurt, Germany;9. BIOSS Centre for Biological Signalling Studies, University of Freiburg, Freiburg, Germany;1. Department of Biology, York University, Toronto, Canada;2. Laboratory of Tissue Repair and Regeneration, Matrix Dynamics Group, Faculty of Dentistry, University of Toronto, Toronto, Canada;3. Division of Cardiovascular Surgery and Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada;4. Department of Internal Medicine I, Division of Cardiology, Friedrich Schiller University Jena, Jena, Germany;5. Division of Cardiology, Department of Medicine, Columbia University Medical Center, New York, USA;1. Laboratorio de Inmunología, Departamento de Sanidad Animal y Medicina Preventiva (SAMP), Centro de Investigación Veterinaria Tandil (CIVETAN-CONICET-CIC), Facultad de Ciencias Veterinarias, Universidad Nacional del Centro de la Provincia de Buenos Aires, Argentina;2. Departamento de Farmacia, Facultad Ciencias Químicas, Unidad de Investigación y Desarrollo en Tecnología Farmacéutica (UNITEFA-CONICET), Universidad Nacional de Córdoba, Argentina;3. Inmunova S.A., Buenos Aires, Argentina;4. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina;1. Molecular and Cellular Pathology, University of Alabama at Birmingham, Birmingham, AL, United States;2. Department of Medical Biochemistry, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai, Tamil Nadu, India |
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| Abstract: | Carnitine is incorporated into a phosphatide as β-methylcholine in several insects. The object of this investigation was to further elucidate the mechanism involved. Cell-free fat-body preparations of Phormia regina larvae catalyse the formation of acyl-carnitines, and this reaction is inhibited by CoA, γ-butyrobetaine, and trimethylamino-propane-1-ol. A minor lipid component was also isolated and this behaved in several tests similar to a phosphatide. In vivo the major carnitine derivative is phosphatidyl-methylcholine whereas in vitro preparations of fat body favour enzymic pathways leading to the formation of long-chain acyl-carnitine derivatives. |
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