Zinc Supplementation Attenuates High Glucose-Induced Epithelial-to-Mesenchymal Transition of Peritoneal Mesothelial Cells |
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| Authors: | Xiuli Zhang Jun Wang Yi Fan Lina Yang Lining Wang Jianfei Ma |
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| Institution: | 1. Department of Nephrology, the First Affiliated Hospital, China Medical University, 155th Nanjing North Street, Shenyang, Liaoning, 110001, People??s Republic of China
2. Department of Nephrology, Benxi Railway Hospital, Benxi, Liaoning, People??s Republic of China
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| Abstract: | Zinc (Zn) plays an important role in preventing many types of epithelial-to-mesenchymal transition (EMT)-driven fibrosis in vivo. But its function in the EMT of the peritoneal mesothelial cells (PMCs) remains unknown. Here, we studied the Zn effect on the high glucose (HG)-induced EMT in the rat PMCs (RPMCs) and the underlying molecular mechanisms. We found that Zn supplementation significantly inhibited TGF-??1 and ROS production, and attenuated the HG-induced EMT in the RPMCs, likely through inhibition of MAPK, NF-??B, and TGF-??/Smad pathways. |
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