ICU机械通气并发下呼吸道医院感染病原菌的调查分析

目的：分析ICU机械通气并发下呼吸道医院感染病原学构成及耐药情况。为临床防治提供依据。方法：对我院1996年6月-1999年6月3间ICU收住的98例机械通气合并下呼吸道医院感染患者的致病菌及药敏结果进行回顾性调查。结果：共检出致病毒128株，其中革兰阴性细菌（G^-菌）占66.4%（85株），革兰阳性细菌（G^ 菌）占25.8%(33株），真菌占7.8%(10株）；前四位致病菌分别为铜绿假单胞菌（24株），革兰阳性细菌（G^ 菌）占25.8%(33株），真菌占7.8%(10株）；前四位致病菌分别为铜绿假单胞菌（24株），金黄色葡萄球菌（22株），不动杆菌属（21株），肠杆菌属（18株），药敏结果显示这类菌株多重耐药现象严重。结论：ICU机械通气并发下呼吸道医院感染病原体构成以G^-菌为主，其药敏试验呈多重耐药，临床应重视病原学检查，开展细菌耐药性监测，合理使用抗菌药物。

ANALYSIS ON THE PATHOGENS OF LOWER RESPIRATORY TRACT INFECTION IN PATIENTS RECEIVING MECHANICAL VENTILATION IN ICU

Objective:To analyze the constitute of the pathogens of lower respiratory tract infection in patients receiving mechanical ventilation in ICU and the pathogens'drug resistance. Methods: The pathogens and their drug resistance of 98 cases patients receiving mechanical ventilation and being complicated with lower respiratory tract infection in ICU were reviewed. Results: 128 strains pathogens were isolated by bacterial culture.The ratio of the gram-negative bacteria to total bacteria isolated was 66^4 percent(85 strains),and the gram-positive bacteria was 25 8 percent (33 strains),the fungi was 7 8 percent (10 strains).Among pathogens the most common were P aeruginosa (24 strains),S aureus(22 strains),Acinebacter(21 strains),Enterobacteriaceae(18 strains).Their drug-resistance-multiple to antimicrobial agents is serious. Conclusion: Gram-negative bacteria were the majority of the pathogens seperated from patients receiving mechanical ventilation of lower respiratory tract infecfion in ICU.The pathogens showes drug-resistomce-mutiple to antimicrobial agents by drug sensitive test.It is suggested that there is urgent need for surveilance of bacterial resistance and rational use of antimicrobial agents should be emphasised during clinical therapy.