The structurally distinct form of pp60c-src detected in neuronal cells is encoded by a unique c-src mRNA. |
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| Authors: | J B Levy T Dorai L H Wang and J S Brugge |
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| Institution: | Department of Microbiology, State University of New York, Stony Brook 11794. |
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| Abstract: | A cellular src (c-src) cDNA clone was isolated from a chicken embryonic brain cDNA library and characterized by DNA sequence analysis. Comparison with the published sequence of a chicken genomic c-src clone indicated that the brain cDNA clone contained an 18-base-pair insertion located between exons 3 and 4 of the c-src gene. The six amino acids encoded by the insertion caused an alteration in the electrophoretic mobility of the c-src gene product similar to that of the structurally distinct form of the src protein detected in neuronal cultures. |
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