Coupled folding during translation initiation |
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| Authors: | Pestova Tatyana V Hellen Christopher U T |
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| Affiliation: | Department of Microbiology and Immunology, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA. |
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| Abstract: | The structure of the eukaryotic initiation factor eIF4E bound to a cognate domain of eIF4G and m(7)GDP in this issue of Cell shows that these factors undergo coupled folding to form a stable complex with high cap binding activity that promotes efficient ribosomal attachment to mRNA during translation initiation. |
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