In vitro susceptibility of Helicobacter pylori to trifluoromethyl ketones |
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| Authors: | Kawase M Harada H Saito S Cui J Tani S |
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| Affiliation: | Faculty of Pharmaceutical Sciences, Josai University, Saitama, Japan. |
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| Abstract: | Heteroaromatic trifluoromethyl ketones (TFMK's) showed strong inhibitory activity against Helicobacter pylori. The MIC50 observed for 2-trifluoroacetonylbenzoxazole (1) is 20-fold more active than metronidazole and is only twice as high as that of clarithromycin. The inhibitory mode of TFMK's on Hp growth was not related to inhibition of urease. |
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