F2-isoprostanes as indices of lipid peroxidation in inflammatory diseases |
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Authors: | Praticò Domenico Rokach Joshua Lawson John FitzGerald Garret A |
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Affiliation: | Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA. |
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Abstract: | Isoprostanes are a new class of lipids, isomers of conventional enzymatically derived prostaglandins, which are produced in vivo primarily by a free radical-catalyzed peroxidation of polyunsaturated fatty acids. F2-isoprostanes, isomers of the enzyme-derived prostaglandin F2alpha, are the most studied species. Because of their mechanisms of formation, specific structural features that distinguish them from other free radical-generated products and chemical stability, they provide a reliable index of the oxidative component of several diseases in vivo. Consistent data suggest that formation of F2-isoprostanes is indeed altered in a variety of clinical settings associated with inflammation and oxidant stress. Moreover, measurement of F2-isoprostanes might provide a sensitive biochemical basis of dose-selection in studies of natural and synthetic antioxidants. |
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