External addition of gramicidin induces the hexagonal HII phase in dioleoylphosphatidylcholine model membranes |
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| Affiliation: | 1. Department of Biochemistry, State University of Utrecht, Padualaan 8, NL 3584 CH Utrecht The Netherlands;2. Institute of Molecular Biology, State University of Utrecht, Padualaan 8, NL 3584 CH Utrecht The Netherlands;3. Department of Molecular Cell Biology, State University of Utrecht, Padualaan 8, NL-3584 CH Utrecht The Netherlands;1. Peking University People''s Hospital, Department of Respiratory and Critical Care Medicine, Beijing, 100044 China;2. School of Nursing, Peking University, Beijing, 100083 China;3. College of Electronic and Information Engineering, Southwest University, Chongqing, 400715 China;4. Curative Medical Technology Inc, Suzhou, 215000 China;1. Department of Pharmacology, Qingdao University School of Pharmacy, Qingdao, Shandong, 266021, China;2. University of Chinese Academy of Sciences, Beijing, 100049, China;1. Department of Cardiology, Wuhan Puai Hospital, Huazhong University of Science and Technology, Wuhan, People''s Republic of China;2. Department of Pathology, Wuhan Puai Hospital, Huazhong University of Science and Technology, Wuhan, People''s Republic of China;1. College of International Studies, Kyung Hee University, Yongin-si 446-701, Republic of Korea;2. Graduate School of Pan-Pacific International Studies, Kyung Hee University, Yongin-si 446-701, Republic of Korea;1. Departamento de Química Inorgánica/Facultade de Química, Instituto de Investigación Biomédica (IBI), Universidade de Vigo, E-36310 Vigo, Galicia, Spain;2. BCMaterials & Departamento de Química Inorgánica, Facultad de Ciencia y Tecnología, Universidad del País Vasco (UPV/EHU), Apartado 644, 48080 Bilbao, Spain |
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| Abstract: | 31P-NMR, small angle X-ray diffraction and freeze-fracture electron microscopy show that dioleoylphosphatidylcholine liposomes undergo a transition from the lamellar to the hexagonal HII phase upon injection of an ethanolic solution of gramicidin in the aqueous medium, when the molar ratio of peptide to lipid is 1 to 20 or higher. |
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