Vasopressin induced production of inositol trisphosphate and calcium efflux in a smooth muscle cell line |
| |
| Affiliation: | 1. Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John''s University, New York, NY, USA;2. Texas Children''s Cancer Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA;3. Institute of Molecular Medicine, Feinstein Institutes for Medical Research, New York, NY, USA;1. Université de Paris, INSERM, Institut Universitaire d''Hématologie, U-944, Paris, France;2. Sorbonne Université, INSERM, Institut Pierre Louis d''épidémiologie et de Santé Publique (IPLESP UMRS 1136), Paris, France;3. Université de Versailles Saint-Quentin-en-Yvelines, UVSQ, UFR de Médecine, Versailles, France;4. Assistance Publique - Hôpitaux de Paris (APHP), Hôpital Ambroise Paré, Service de Médecine Interne, Boulogne Billancourt, France |
| |
| Abstract: | Phosphatidylinositol metabolism and 45Ca2+ efflux were examined in a vascular smooth muscle cell line (A7r5). [Arg8]Vasopressin stimulated the rapid formation (measurable at 1 sec) of inositol phosphates in a concentration-dependent manner. The time course for formation of inositol phosphates was similar to that for 45Ca2+ efflux from preloaded cells. The efflux of 45Ca2+ in response to [Arg8]vasopressin could be inhibited by a vasopressin antagonist. This supports the hypothesis that inositol 1,4,5-trisphosphate plays a role in vasopressin stimulated calcium mobilisation from an intracellular source in cultured vascular smooth muscle cells. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
