Transport of l-ascorbic acid and dehydro-l-ascorbic acid across renal cortical basolateral membrane vesicles |
| |
| Affiliation: | 1. Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA;2. Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA;3. Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02142 USA;1. Jiangsu Key Laboratory of Environmental Science and Engineering, School of Environmental Science and Engineering, Suzhou University of Science and Technology, Suzhou 215009, China;2. Department of Land, Air and Water Resources, University of California, Davis, CA 95616, USA |
| |
| Abstract: | The uptake of l-ascorbic acid and dehydro-l-ascorbic acid into renal cortical basolateral membrane vesicles has been characterized. The uptake systems for both solutes demonstrate saturation kinetics. The presence of structural analogs of l-ascorbic acid and dehydro-l-ascorbic acid results in cis-inhibition and trans-stimulation. Uptake of each substrate is Na+-independent, proceeding to an endpoint of substrate equilibrium across the vesicular membrane. The transport mechanism(s) for l-ascorbic acid and dehydro-l-ascorbic acid appears to be facilitated diffusion. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
