Phorbol ester stimulates calcitonin secretion synergistically with A23187, and additively with dibutyryl cyclic AMP in a rat C-cell line |
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| Affiliation: | 1. Department of Botany, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan;2. Department of Botany, University of Chakwal, Chakwal 48800, Pakistan;3. Department of Botany, University of Gujrat, Gujrat, Punjab 50700, Pakistan;4. Department of Oral and Maxillofacial Surgery, College of Dentistry, King Saud University, Riyadh – 11545, Saudi Arabia;5. Department of Botany, Hindu College Moradabad (Mahatma Jyotiba Phule Rohilkhand University, Bareilly), 244001, India |
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| Abstract: | The mechanism of action of 12-O-tetradecanoyl phorbol-13-acetate (TPA) on calcitonin secretion was studied in a rat C-cell line, rMTC 6–23. TPA stimulated calcitonin secretion at the concentration of 16nM. This effect was synergistically enhanced with calcium ionophore, A23187. Synthetic diacylglycerol, 1-oleoyl-2-acetyl-glycerol (OAG), also showed a synergism with A23187 on calcitonin secretion. When dibutyryl cyclic AMP was added with TPA, an additive effect was obtained. These data suggest that C-kinase might be a possible regulator of calcitonin secretion in addition to the cyclic AMP-mediated pathway. |
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