Phosphorylation of the rat hepatocyte asialoglycoprotein receptor期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Phosphorylation of the rat hepatocyte asialoglycoprotein receptor

Institution:	1. ANSES, Risk Assessment Department, Maisons-Alfort, France;2. Institute of Environmental Medicine (IMM), Karolinska Institutet, Sweden;3. National Institute for Public Health and the Environment (RIVM), The Netherlands.;4. Agency for Health and Food Safety GmbH (AGES), Austria;1. Department of Reproductive Medicine, Oslo University Hospital, Oslo, Norway;2. Department of Gynaecology, Erasmus Medical Centre Rotterdam, Rotterdam, The Netherlands;3. Current address: Department of Otorhinolaryngology, HagaHospital, The Hague, The Netherlands;4. Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway;5. Department of Pathology, Oslo University Hospital, Norwegian Radium Hospital, Oslo, Norway

Abstract:	Phosphorylation of asialoglycoprotein receptor was investigated by using rat hepatocytes. Analysis of the purified receptor by SDS-PAGE and autoradiogram revealed that the 64 and 54 Kd polypeptides of the receptor were phosphorylated but the 43 Kd one was not and that phosphorylation took place at the cell surface. These results are compatible with the fact that the 64 and 54 Kd species exist predominantly at the cell surface. The sites of phosphorylation were identified as Ser and Thr with no detectable radioactivity in phosphotyrosine.

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