Synthesis and biological activity of the 1alpha,25-dihydroxyvitamin D3 diastereomer with unnatural configuration at the rings C/D side-chain moiety |
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| Authors: | Marczak S Przezdziecka A Wicha J Steinmeyer A Zügel U |
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| Affiliation: | Institute of Organic Chemistry, Polish Academy of Sciences, Warsaw. |
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| Abstract: | 1Alpha,25-dihydroxyvitamin D3 diastereomer, differing from the parent compound in configuration at four asymmetric carbon atoms in the rings C/D and side chain (C13, C14, C17 and C20), was synthesized and shown to have a significant affinity for the vitamin D receptor. |
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