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Identification and Genetic Characterization of Mutants of Bacteriophage T4 Defective in the Ability to Induce Exonuclease A |
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| Authors: | Huber R. Warner D. Peter Snustad James F. Koerner J. D. Childs |
| Affiliation: | Department of Biochemistry and Department of Genetics and Cell Biology, College of Biological Sciences, University of Minnesota, St. Paul, Minnesota 55101;Department of Biochemistry, Medical School, University of Minnesota, Minneapolis, Minnesota 55455;Biology and Health Physics Division, Atomic Energy of Canada Limited, Chalk River, Ontario, Canada |
| Abstract: | A mutant of bacteriophage T4 unable to induce exonuclease A has been isolated. The mutation responsible for this defect maps between genes 39 and 56, in a region of the chromosome devoid of other known markers. Four deletion mutants lacking part of the genome located between genes 39 and 56 also fail to induce exonuclease A. The ability of all of these mutants to replicate suggests that exonuclease A is not essential for replication of phage T4. |
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