Metal Ion-Biomolecule Interactions. VIII: Methylmercury(II) Complexes of 8-Thioguanosine. Synthesis and Spectroscopic Investigations |
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Authors: | AR Norris R Kumar E Buncel |
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Institution: | Department of Chemistry, Queen''s University, Kingston, Canada, K7L 3N6 |
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Abstract: | The reaction of 8-thioguanosine (8-thioGuoH2 with methylmercury(II) has been shown to give rise to 1:1 (neutral and cationic), 1:2 (neutral and cationic), and 1:3 (cationic) complexes of the type CH3Hg(8-thioGuoH)], (CH3Hg(8-thioGuoH2)]NO3, (CH3Hg)2(8-thioGuo)], (CH3Hg)2(8-thioGuoH)]NO3 and (CH3Hg)3(8-thioGuo)]NO3, depending upon the reactant stoichiometry and pH. 1H NMR, 13C NMR, and IR, as well as analytical data were used to characterize the complexes. Coupling of methylmercury(II)-protons to mercury-199 has been observed in all compounds. The magnitude of the coupling, 2J(1H-199Hg), is strongly dependent on the nature of the ligand bonded to the methylmercury(II) group and correlates with the 13C chemical shifts of coordinated CH3Hg(II) at the different binding sites. |
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Keywords: | Address reprint requests to Dr A R Norris Department of Chemistry Queen's University Kingston Canada K7L 3N6 |
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