The Reaction of Pt-Antitumor Drugs with Selected Nucleophiles.: II. Preparation and Characterization of Coordination Compounds of Pt(II) andl-Histidine |
| |
| Authors: | V. Saudek H. Pivcová D. Nosková J. Drobnik |
| |
| Affiliation: | Institute of Macromolecular Chemistry, Czechoslovak Academy of Sciences, Prague, Czechoslovakia |
| |
| Abstract: | Various His-Pt(II) coordination compounds were prepared by reaction of K2PtCl4 or cis-[Pt(NH3)2Cl2](cis-DDP) with His and analyzed by 1H and 13C NMR spectroscopy, electrophoresis, and ion-exchange chromatography. His may be coordinated to Pt by the imidazol iminogroup and/or the α-aminogroup; the carboxy group remains always free. Both bidentate as well as monodentate ligands were identified. Cis-DDP reacts with His to give a mixture of compounds where all these possibilities are present: cis-diamine-(histidine-N,N-)Pt(II) and three different types of cis-diammine-bis(histidine). HCl trans cleavage of compounds with bidentate His ligands leads to a mixture of two compounds having His ligated to Pt by an amino or imin group. The methods applied are suitable for analyzing reactions of His with cis-DDP under model conditions similar to physiological conditions. |
| |
| Keywords: | Address reprint requests to Dr. H.A. Tajmir-Riahi Department of Chemistry University of Montreal C.P. 6210 Station A Montreal Quebec Canada. |
| 本文献已被 ScienceDirect 等数据库收录！ |
