Metal ion biomolecule interactions. VI: Synthesis and spectroscopic properties of methylmercury(II) complexes of xanthosine |
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| Authors: | E Buncel BK Hunter R Kumar AR Norris |
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| Institution: | Department of Chemistry, Queen''s University, Kingston, Canada |
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| Abstract: | The interaction of MeHg(II) with xanthosine (Xanth H2, 1) in aqueous medium has been found to lead to several methylmercurated complexes depending on the reactant stoichiometries and the pH. The N-bound complexes (MeHg)(Xanth H)] (2), (MeHg)2Xanth] (3), (MeHg)3(Xanth)]NO3 (4), (MeHg)(Xanth H2)]NO3 (5), and the N- and C-bound complex (MeHg)4(Xanth)]NO3 (6) have thus been prepared. The complexes were characterized by means of 1H and 13C nuclear magnetic resonance and infrared as well as elemental analysis. Formation of the carbon-bound methylmercurated species 6 is in accord with our previous results obtained with inosine and imidazole derivatives, thus substantiating our proposal that activation through electrophilic coordination at N7 is a requirement for C8-H abstraction. Correlations are drawn between 2J(1H-119Hg) values and pKa as well as 13C chemical shifts. |
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